從事骨科臨床工作十余年，專注于微創(chuàng)脊柱外科領(lǐng)域。擅長(zhǎng)骨質(zhì)疏松癥及其相關(guān)性椎體骨折、腰椎間盤突出、腰椎管狹窄、腰椎滑脫、頸椎病等退行性疾病，以及脊柱感染和脊柱創(chuàng)傷骨折等脊柱疾病的診斷及微創(chuàng)手術(shù)治療。

中山大學(xué)附屬第三醫(yī)院脊柱外科 副主任醫(yī)師，碩士生導(dǎo)師

本科畢業(yè)于中南大學(xué)湘雅醫(yī)學(xué)院，在中山大學(xué)獲得碩士及博士學(xué)位。

已發(fā)表的學(xué)術(shù)論著?(#equal contribution,*corresponding author)

1. Shangfu Li#*, Qiuli Liu#, Depeng Wu#, Tianwei He, Jinbo Yuan, HengQiu, Jennifer Tickner, Song GuoZheng, Xiaojuan Li, JiakeXu*, LiminRong*. PKC-delta deficiency in B cells displays osteopenia accompanied with upregulation of RANKL expression and osteoclast-osteoblast uncoupling, Cell death & disease?2020; 11(9): 762. (IF=8.469)
2. Shangfu Li#*, Tianwei He#, Depeng Wu#, Liangming Zhang, Ruiqiang Chen, Bin Liu, Jinbo Yuan, Jennifer Tickner, An Qin, JiakeXu, LiminRong*. Conditional Knockout of PKC-delta in Osteoclasts Favors Bone Mass Accrual in Males Due to Decreased Osteoclast Function, Frontiers in cell and developmental biology, 2020; 8: 450. (IF=6.684)
3. Shangfu Li, Ruiqiang Chen, Yuyong Chen, Guoshu Mo, Liangming Zhang, FengFeng, Bu Yang, PeigenXie, Qiyou Wang, Bin Liu, Jianwen Dong, LiminRong*. Therapeutic effects and safety of percutaneous disc decompression with coblationnucleoplasty in cervical vertigo: A retrospective outcome study with 74 consecutive patients and minimum 1-year follow-up, Pain Physician?2019; 22(3): E205-E214. (IF=4.965)
4. Shangfu Li#, Bu Yang#, Dian Teguh, Lin Zhou, Jiake Xu, Limin Rong*. Amyloid beta Peptide Enhances RANKL-Induced Osteoclast Activation through NF-kappaB, ERK, and Calcium Oscillation Signaling. International journal of molecular sciences?2016; 17(10). (IF=5.923)
5. Shangfu Li#, Bin Liu#, Ming Tian, Liangming Zhang, Jennifer Tickner, Jiake Xu, Limin Rong *. An effective and practical immunohistochemical protocol for bone specimens characterized by hyaluronidase and pepsin predigestion combined with alkaline phosphatase -mediated chromogenic detection. Histology and Histopathology?2015; 30(3):331-43. (IF=2.303)
6. Shangfu Li, Bin Liu, Liangming Zhang, Limin Rong*. Amyloid beta peptide is elevated in osteoporotic bone tissues and enhances osteoclast function.Bone?2014; 61: 164-175. (IF=4.398)
7. Bu Yang#, Shangfu Li#, Zheng Chen#, FengFeng, Lei He, Bin Liu, Tianwei He, Xuan Wang, Ruiqiang Chen, Zihao Chen, PeigenXie*, LiminRong*. Amyloid beta peptide promotes bone formation by regulating Wnt/beta-catenin signaling and the OPG/RANKL/RANK system, FASEB Journal?2020; 34(3): 3583-3593. (IF=5.191)
8. Lin Zhou#, Guoju Hong#, Shangfu Li#, Qian Liu, Fangming Song, Jinmin Zhao, Jinbo Yuan, Jennifer Tickner, JiakeXu*. Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling, International journal of biological sciences?2020; 16(2): 309-319. (IF=6.580)
9. Tianwei He#, Depeng Wu#, Lei He#, Xuan Wang, Bu Yang, Shangfu Li, Yuyong Chen, Kun Wang, Ruiqiang Chen, Bin Liu, Liangming Zhang, LiminRong. Casein kinase 1 epsilon facilitates cartilage destruction in osteoarthritis through JNK pathway. FASEB journal?2020; 34(5): 6466-6478. (IF=5.191)
10. Zihao Chen#, Liangming Zhang#, Jianwen Dong, PeigenXie, Bin Liu, Qiyou Wang, Ruiqiang Chen, Tao Shu, Shangfu Li, FengFeng, Bu Yang, Lei He, Yang Yang, Zhongyu Liu, Mao Pang, LiminRong*. Percutaneous Transforaminal Endoscopic Discectomy VersusMicroendoscopic Discectomy for Lumbar Disc Herniation: Two-Year Results of a Randomized Controlled Trial. Spine?2019; 45(8): 493-503. (IF=3.468)
11. Zihao Chen#, Liangming Zhang#, Jianwen Dong, PeigenXie, Bin Liu, Qiyou Wang, Ruiqiang Chen, FengFeng, Bu Yang, Tao Shu, Shangfu Li, Yang Yang, Lei He, Mao Pang, LiminRong*. Percutaneous transforaminal endoscopic discectomy compared with microendoscopic discectomy for lumbar disc herniation: 1-year results of an ongoing randomized controlled trial. Journal of neurosurgery. Spine?2018; 28(3): 300-310. (IF=3.602)
12. Chang Liu#, Yong Huang#, Mao Pang#, Yang Yang, Shangfu Li, Linshan Liu, Tao Shu, Wei Zhou, Xuan Wang, Limin Rong*, Bin Liu*. Tissue-engineered regeneration of completely transected spinal cord using induced neural stem cells and gelatin-electrospunpoly(lactide-co- glycolide)/polyethylene glycol scaffolds. Plos one?2015; 10(3): e0117709. (IF=3.240)
13. Wei Zhou#, Peigen Xie#, Mao Pang#, Bu Yang, Youqiang Fang, Tao Shu, Chang Liu, Xuan Wang, Liangming Zhang, Shangfu Li, Limin Rong*. Upregulation of CRMP4, a new prostate cancer metastasis suppressor gene, inhibits tumor growth in a nude mouse intratibial injection model. Int J Oncol?2015; 46: 290-298. (IF=5.650)

?

以主持人和核心成員身份獲得的科研資助項(xiàng)目（按時(shí)間倒序排列）

廣東省自然科學(xué)基金面上項(xiàng)目，PKC-δ通過(guò)雄激素受體信號(hào)通路性別依賴性調(diào)控雄鼠破骨細(xì)胞骨吸收功能的機(jī)制研究，項(xiàng)目負(fù)責(zé)人，編號(hào)2021A1515010316，2021.01-2023.12，10萬(wàn)

廣州市科技計(jì)劃市校（院）聯(lián)合資助項(xiàng)目，PKC-δ介導(dǎo)B細(xì)胞分泌RANKL導(dǎo)致破骨細(xì)胞-成骨細(xì)胞失藕聯(lián)及骨丟失的骨免疫學(xué)機(jī)制研究，項(xiàng)目負(fù)責(zé)人，編號(hào)202102010187，2021.04-2023.03，20萬(wàn)

國(guó)家自然科學(xué)基金面上項(xiàng)目，CK1ε通過(guò)Wnt/JNK通路促進(jìn)骨性關(guān)節(jié)炎軟骨退變的作用及其機(jī)制研究，排名第三，編號(hào)81972111，2020.01-2023.12，55萬(wàn)

廣東省科技創(chuàng)新戰(zhàn)略專項(xiàng)基金自由申請(qǐng)項(xiàng)目，抗癡呆藥物Donepezil治療骨質(zhì)疏松作用及其抑制骨吸收的機(jī)制研究，項(xiàng)目負(fù)責(zé)人，編號(hào)2018A030313248，2018.05-2021.04，10萬(wàn)

中山大學(xué)附屬第三醫(yī)院臨床研究計(jì)劃啟航項(xiàng)目，經(jīng)皮髓核成形術(shù)治療頸性眩暈臨床療效和安全性的單中心、隨機(jī)對(duì)照、前瞻性隊(duì)列研究，項(xiàng)目負(fù)責(zé)人，編號(hào)QHJH201809，2018.03-2020.03，5萬(wàn)

中山大學(xué)高?；究蒲袠I(yè)務(wù)費(fèi)—青年教師培育項(xiàng)目，破骨細(xì)胞PKC-δ基因條件性敲除后骨吸收功能改變及其分子機(jī)制，項(xiàng)目負(fù)責(zé)人，編號(hào)17ykpy49，2017.01-2019.12，15萬(wàn)

廣東省自然科學(xué)基金-博士科研啟動(dòng)項(xiàng)目，β-淀粉樣蛋白通過(guò)過(guò)度激活破骨細(xì)胞與加速成骨細(xì)胞凋亡促進(jìn)骨質(zhì)疏松發(fā)展的機(jī)制研究，項(xiàng)目負(fù)責(zé)人，編號(hào)2014A030310109，2015.01-2017.12，10萬(wàn)

國(guó)家自然科學(xué)基金面上項(xiàng)目，Aβ蛋白促骨質(zhì)疏松作用及其介導(dǎo)的破骨細(xì)胞-成骨細(xì)胞失平衡的機(jī)制研究，排名第二，編號(hào)81472122，2015.01-2018.12，72萬(wàn)

?