許燕 研究員，博士研究生導師，博士畢業(yè)于中國科學院大學，2017年通過中山大學“百人計劃”加入中山大學附屬第三醫(yī)院。在體細胞重編程和肝臟疾病發(fā)生機制等方面以第一作者/通訊作者在Cell Stem Cell, Journal of Hepatology, Nature Materials, Trends in Cell Biology等國際權(quán)威期刊發(fā)表學術(shù)論文多篇，研究獲得國家重點研發(fā)計劃、國家自然科學基金、廣東省自然科學基金等基金支持。

?

研究方向及意義：

1.干細胞分化機制及其在肝臟疾病治療中的作用與機制研究；

2.肝臟再生修復中的表觀遺傳和轉(zhuǎn)錄調(diào)控機制研究。

代表性研究成果：

1. Huaxin Chen^#, JianyeCai^#, Jiancheng Wang^#, Yuan Qiu, Chenhao Jiang, Yi Wang, Guo lv, Lijie Pan, Yuanjun Guan, Jun Zheng, DongboQiu, Cong Du, Qiuli Liu, Guihua Chen, Yang Yang^*, Yan Xu^*, Andy Peng Xiang^*,Qi Zhang^*. Targeting Nestin-positive hepatic stellate cells ameliorates liver fibrosis by modulating Caveolin-mediated TβRI degradation. Journal of Hepatology.2021 May;74(5):1176-1187.
2. Qiuli Liu^#, Xiaoyong Chen^#, Chang Liu^#, Lijie Pan, Xinmei Kang, Yanli Li, Cong Du, Shuai Dong, Andy Peng Xiang^*, Yan Xu^*, Qi Zhang^*. Mesenchymal Stem Cells Alleviate Experimental Immune-mediated Liver Injury via Chitinase 3-like protein 1-mediated T cell suppression. Cell Death Dis. 2021 Mar 4;12(3):240.
3. Yan Xu, Qi Zhang. Chapter 15 - Clinical Application of Stem Cells in Liver Diseases: From Bench to Bedside. Stem Cells and Cancer in Hepatology: From the Essentials to Application. https://doi.org/10.1016/C2016-0-03399-5, Pages 317-346 (2018).
4. Yan Xu^#, Meng Zhang^#, Wenjuan Li, Xihua Zhu, XichenBao, Baoming Qin, Andrew P Hutchins^*, Miguel A Esteban^*. Transcriptional Control of Somatic Cell Reprogramming. Trends Cell Biol. 2016 Apr;26(4):272-288.
5. Longqi Liu^#, Yan Xu^#, *, Minghui He^#, Meng Zhang, Fenggong Cui, Leina Lu, Mingze Yao, WeihuaTian, Christina Benda, QiangZhuang, Zhijian Huang, Wenjuan Li, Xiangchun Li, Ping Zhao, Wenxia Fan, ZhiweiLuo, Yuan Li, Yasong Wu, Andrew P Hutchins, Dongye Wang, Hung-Fat Tse, Axel Schambach, Jon Frampton, Baoming Qin, XichenBao, Hongjie Yao, Biliang Zhang, Hao Sun, Duanqing Pei, Huating Wang, Jun Wang, Miguel A Esteban^*. Transcriptional pause release is a rate-limiting step for somatic cell reprogramming. Cell Stem Cell. 2014 Nov 6;15(5):574-88.
6. Yan Xu, Longqi Liu, Andrew L Laslett, Miguel A Esteban. Cell reprogramming: Into the grooveNat Mater. 2013 Dec;12(12):1082-4. doi: 10.1038/nmat3821.
7. Cancan Xu, Zhuowei Zhou, Chang Liu, Xinmei Kang, XiaofenZhong, Qi Zhang^?, Yan Xu^?. Generation of a DAPK1 knockout first (conditional ready) human embryonic stem cell line (ZSSYe001-A) by CRISPR-Cas9 technology. Stem Cell Research 43, March 2020.
8. Huijiao Wu^#, Cong Du^#, Fan Yang^#, XiaofangZheng, DongboQiu, Qi Zhang, Wenjie Chen^*, Yan Xu^*. Generation of hepatocyte-like cells from human urinary epithelial cells and the role of autophagy during direct reprogramming. BiochemBiophys Res Commun. 2020 Jun 30;527(3):723-729.
9. MIGUEL ANGEL ESTEBAN BARRAGAN、秦寶明、鮑習琛、劉龍奇、許燕、吳海濤、朱細華、郭享彭、吳亞松、李媛、莊強、卿小兵、駱志偉、黃穎華、張輝，尿液誘導多能干細胞技術(shù)及體細胞重編程機制，廣東省自然科學獎，一等獎，2019年，中國科學院廣州生物醫(yī)藥與健康研究院

?

其他學術(shù)活動：

1. 中國機械工程學會生物制造工程分會第二屆委員會委員
2. Frontiers in Cell and Developmental Biology雜志Guest editor，負責research topic“Targeting Heterogeneity of Mesenchymal Stem Cells”的編輯；
3. 擔任Molecular?Therapy?-?Nucleic?Acids，Stem Cell Research & Therapy，F(xiàn)rontiers in Cell and Developmental Biology，Cell?Biology?and?Toxicology，World Journal of Surgical Oncology，Medical Science Monitor等雜志審稿人。

?

?