擅長(zhǎng)以高通量測(cè)序、高通量篩選、單細(xì)胞測(cè)序、大數(shù)據(jù)挖掘和動(dòng)物細(xì)胞模型構(gòu)建等為手段，從事細(xì)胞代謝特征與疾病的發(fā)生發(fā)展及其在藥物篩選新靶點(diǎn)發(fā)現(xiàn)、高通量藥物發(fā)現(xiàn)中的應(yīng)用等相關(guān)的研究。

李莎莎，生物信息學(xué)博士，中山大學(xué)“百人計(jì)劃”引進(jìn)人才，2018年于清華大學(xué)獲得博士學(xué)位，隨后在美國(guó)密歇根大學(xué)鄒偉平教授實(shí)驗(yàn)室從事3年博士后研究工作，長(zhǎng)期以高通量測(cè)序、高通量篩選、單細(xì)胞測(cè)序、大數(shù)據(jù)挖掘和動(dòng)物細(xì)胞模型構(gòu)建等為手段，從事細(xì)胞代謝特征與疾病的發(fā)生發(fā)展及其在藥物篩選新靶點(diǎn)發(fā)現(xiàn)、高通量藥物發(fā)現(xiàn)中的應(yīng)用等相關(guān)的研究。相關(guān)工作在Science Advances, Cell Reports, Protein & Cell, Annals of the Rheumatic Diseases, Nature Medicine 等雜志發(fā)表學(xué)術(shù)論文22余篇、開發(fā)數(shù)個(gè)原創(chuàng)數(shù)據(jù)分析網(wǎng)站，申請(qǐng)發(fā)明專利多項(xiàng)，H-index為17，谷歌學(xué)術(shù)論文被引超過1100次，單篇發(fā)表兩年內(nèi)被引280次，獲ESI Top 1% 高被引論文（詳見：https://www.researchgate.net/profile/Shasha-Li-10）。主持中山大學(xué)“百人計(jì)劃”引進(jìn)人才啟動(dòng)經(jīng)費(fèi)項(xiàng)目、廣東省自然科學(xué)基金面上項(xiàng)目、廣東省企業(yè)聯(lián)合基金等項(xiàng)目。

?

代表性研究成果：

1. Gaopeng Li*, Jae Eun Choi, Ilona Kryczek, Yilun Sun, Peng Liao, Shasha Li, Shuang Wei, Sara Grove, Linda Vatan, Reagan Nelson, Grace Schaefer, Steven G. Allen, Kamya Sankar, Leslie A. Fecher, Mishal Mendiratta-Lala, Timothy L. Frankel, Angel Qin, Jessica J. Waninger, Alangoya Tezel, Ajjai Alva, Christopher D. Lao, Nithya Ramnath, Marcin Cieslik, Paul W. Harms, Michael D. Green, Arul M. Chinnaiyan, Weiping Zou. Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy. Cancer cell. 2023
2. Shasha Li*, Jiali Yu*, Amanda Huber, Ilona Kryczek, Zhuwen Wang, Long Jiang, Xiong Li, Wan Du, Gaopeng Li, Marcin Cieslik, Shuang Wei, Linda Vatan, Wojciech Szeliga, Arul M. Chinnaiyan, Michael D. Green, Weiping Zou. Metabolism drives macrophage heterogeneity in the tumor microenvironment. Cell Reports. 2022
3. Shasha Li*, Chenyang Lu*, Yuan Zhang, Xiaolu Zhao, Kequan Lin, Xiufang Kong, David Fox, Lixiang Xue, Lichao Sun, Yi Liu, Fengbiao Mao. Genetic association and single-cell transcriptome analyses reveal distinct features connecting autoimmunity with cancers. iScience. 2022
4. Haiyan Wang*, Shasha Li*, Zhenshuo Jin, Shao Wei, Yan Gao, Lu Li, Kequan Lin, Lin zhu, Huili Wang, Xuebin Liao, Dong Wang. Tumor Immunological Phenotype Signature-based Drug Screening Reveals Aurora Kinase Inhibitors Enhancing Immunotherapy Efficacy. Science Advances. 2021
5. Shasha Li*, Wenli Liu*, liqin Wang, Xiaoping An, Lihua Song, Yigang Tong, Huahao Fan, Chenyang Lu. Cepharanthine shows anti-viral activities by modulating cellular stress responses triggered by a SARS-CoV-2 related coronavirus. Briefings in bioinformatics. 2021
6. Jiajia Zhou*, Ilona Kryczek, Shasha Li, Xiong Li, Angelo Aguilar, Shuang Wei, Sara Grove, Jiali Yu, Peng Liao, Yijian Yan, Jing Li, Wan Du, Linda Vatan, Weimin Wang, Shaomeng Wang, and Weiping Zou*. MDM2 sustains STAT5 stability to control T cell-mediated anti-tumor immunity. Nature immunology. 2021
7. Heng Lin*, Ilona Kryczek, Shasha Li, Michael D. Green, Alicia Ali, Reema Hamasha, Shuang Wei, Linda Vatan, Wojciech Szeliga, Sara Grove, Xiong Li, Jing Li, Weichao Wang, Yijian Yan, Jae Eun Choi, Gaopeng Li, Yingjie Bian, Ying Xu, Jiajia Zhou, Jiali Yu, Houjun Xia, Weimin Wang, Ajjai Alva, Arul Chinnaiyan, Marcin Cieslik, and Weiping Zou. Stanniocalcin-1 drives tumor resistance to immunotherapy via targeting APCs. Cancer cell. 2021
8. Wan Du*, Fang Hua*, Xiong Li, Jian Zhang, Shasha Li, Weichao Wang, Jiajia Zhou, Weimin Wang, Peng Liao, Yijian Yan, Gaopeng Li, Shuang Wei, Sara Grove, Ilona Kryczek, Xiong Li, Angelo Aguilar, Shuang Wei, Sara Grove, Linda Vatan, Witold Zgodzinski, Marek Majewski, Grzegorz Wallner, Haoyan Chen, Ilona Kryczek , Jing-Yuan Fang, and Weiping Zou. Loss of optineurin drives cancer immune evasion via palmitoylation-dependent IFNGR1 lysosomal sorting and degradation. Cancer Discovery. 2021
9. Gaopeng Li, Ilona Kryczek, Jutaek Nam, Xiong Li, Shasha Li, Jing Li, Shuang Wei, Sara Grove, Linda Vatan, Jiajia Zhou, Wan Du, Heng Lin, Ton Wang, Chitra Subramanian, James J. Moon, Marcin Cieslik, Mark Cohen, and Weiping Zou. LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy. Nature cell biology. 2021
10. Chenyang Lu*, Shasha Li*, Yi Liu. Role of immunosuppressive therapy in rheumatic diseases concurrent with covid-19. Annals of the Rheumatic Diseases 2020
11. Jiali Yu*, Michael D. Green*, Shasha Li, Sara Journey, Jae Eu Choi, Syed Monem Rizvi, Angel Qin, Jessica F. Waninger.., Ajjai Alva, and Weiping Zou. Liver metastasis restrains immunotherapy efficacy via myeloid-mediated T-cell elimination. Nature medicine. 2020
12. Houjun Xia*, Shasha Li, Xiong Li, Weichao Wang, Yingjie Bian, Shuang Wei, Sara Grove, Jun-Lin Guan, Ilona Kryczek, and Weiping Zou. Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis. JCI insight. 2020
13. Yingjie Bian*, Wei Li*, Daniel M. Kremer, Peter Sajjakulnukit, Shasha Li, Joel Crespo, Zeribe C. Nwosu, Li Zhang…, Ilona Kryczek, Costas A.Lyssiotis, and Weiping Zou. Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Nature. 2020
14. Wei Shao*, Shasha Li*, Lu Li, Kequan Lin, Xinhong Liu, Haiyan Wang, Huili, Wang, Dong Wang. Chemical Genomics Reveals Inhibition of Breast Cancer Lung Metastasis by Ponatinib via c-Jun. Protein & Cell. 2019
15. Shuaishuai Teng, Yang Li, Ming Yang, Rui Qi, Yiming Huang, Qianyu Wang, Shasha Li, Kequan Lin, Yujing Cheng, Zhi John Lu, Dong Wang. Epigenetic Reprogramming of Tissue-Specific Transcription Promotes Metastasis. Cell research. 2019
16. Shasha Li*, Shuaishuai Teng*, Junquan Xu, Guannan Su, Yu Zhang, Jianqing Zhao, Suwei Zhang, Haiyan Wang, Wenyan Qin, Zhi John Lu, Qianyong Zhu, Dong Wang. Microarray is an efficient tool for circRNA profiling. Briefings in bioinformatics. 2018 (ESI Top 1% 高被引論文)
17. Yong Huang*, Shasha Li*, Qiumin Zhao, Guangqian Pei, Xiaoping An, Zhiqiang Mi, Jiusong Zhang and Yigang Tong. Isolation and characterization of a novel invertebrate iridovirus from adult Anopheles minimus (AMIV) in China. Journal of Invertebrate Pathology. 2015
18. Shasha Li*,?Xiaoping An*, Yong Huang, Guangqian Pei, Dong Cao, Zhiqiang Mi, Zhida Gu, Xiaotong Zhao, Jingyun Li, Guibo Gu and Yigang Tong. Source tracking of an anthrax outbreak in northeastern China using complete genome analysis and MLVA genotyping. Eur J Clin Microbiol. 2014
19. Shasha Li*, Hang Fan*, Xiaoping An, Huahao Fan, Huanhuan Jiang, Yubao Chen and Yigang Tong. Scrutinizing Virus Genome Termini by High throughput Sequencing. Plos One. 2013